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Peutz-Jeghers Syndrome - JMI ArticlesArticles in our collection about Peutz-Jeghers Syndrome published during the 1950sTitle: GASTRO-INTESTINAL ADENOMATOSIS WITH ORAL PIGMENTATION Authors: MARTIN L. BRADFORD, LAMONT E. DANZIG Journal: BOSTON MEDICAL QUARTERLY Date: 1950 Abstract: ATTENTION HAS RECENTLY BEEN FOCUSED ON THE ASSOCIATION OF A DISTINCTIVE TYPE OF ORAL MELANOSIS WITH GENERALIZED INTESTINAL POLYPOSIS. THE FIRST SPECIFIC REFERENCE CONCERNING THIS DISORDER, AND THE EARLIEST TO STRESS THE ASSOCIATION OF PIGMENTATION AND INTESTINAL POLYPOSIS BY A SPECIFIC TITLE, IS A PAPER OF 1921 BY PEUTZ, WHO DESCRIBED CASE HISTORIES IN SEVERAL MEMBERS OF THE SAME FAMILY. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND MELANIN SPOTS Authors: Journal: JAMA Date: 1950 Abstract: JEGHERS AND HIS ASSOCIATES SAY THAT IN 1944 ONE OF THEM REPORTED 2 PATIENTS WITH A DISTINCTIVE TYPE OF MELANIN PIGMENTATION OF THE ORAL MUCOSA, LIPS AND DIGITS ASSOCIATED WITH INTESTINAL POLYPOSIS. Link: Click here to read article Title: SYNDROME OF CIRCUMORAL PIGMENTATION ASSOCIATED WITH GENERALIZED INTESTINAL POLYPOSIS: REPORT OF A CASE Authors: BEN F. PERRY, JOSEPH J. ZUSKA Journal: U.S. ARMED FORCES MEDICAL JOURNAL Date: 1950 Abstract: HUTCHINSON IN 1896 PUBLISHED A REPORT OF IDENTICAL TWINS WHO BOTH PRESENTED A PECULIAR PIGMENTATION ABOUT THE MOUTH, A FACT WHICH WAS THEN REGARDED AS A DERMATOLOGIC CURIOSITY. WEBER IN 1919 RECORDED THE DEATH OF ONE OF THESE TWINS FROM INTUSSUSCEPTION. ALTHOUGH THERE WAS NO POST-MORTEM CONFIRMATION OF INTESTINAL POLYPOSIS, IT SEEMS LIKELY THAT THESE TWINS SUFFERED FROM THE SYNDROME TO BE DISCUSSED. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH MELANIN SPOTS OF THE ORAL MUCOSA-SYNDROME OF PEUTZ Authors: O. D. FISHER Journal: REPRINTED FROM GREAT ORMOND STREET JOURNAL Date: 1951 Abstract: PEUTZ (1921) FIRST DREW ATTENTION TO THE ASSOCIATION OF INTESTINAL POLYPI AND PIGMENTED SPOTS OF THE MOUTH OCCURRING IN SEVERAL MEMBERS OF A FAMILY. THIS CONDITION HAS BEEN RECENTLY REVIEWED BY JEGHERS ET AL. (1949), WHO ADDED A FURTHER 10 CASES AND COLLECTED 12 FROM THE WORLD LITERATURE, WHICH INCLUDED TWO MEMBERS OF A WELSH FAMILY DESCRIBED BY, FOSTER (1944). A FURTHER CASE HAS BEEN RECORDED IN ENGLAND BY TANNER (1951). Link: Click here to read article Title: FAMILIAL INTESTINAL POLYPOSIS Authors: E. MONTUSCHI Journal: LANCET Date: 1952 Abstract: DR. WOLFF'S INTERESTING PAPER (MARCH 1) ON A CASE OF FAMILIAL INTESTINAL POLYPOSIS WITH PIGMENTATION OF LIPS, ORAL MUCOSA, FACE, AND DIGITS, PROMPTS ME TO RECORD BRIEFLY A CASE WHICH I SAW SOME TIME AGO AT THE ITALIAN HOSPITAL, WHICH SUGGESTS THE EXISTENCE OF INCOMPLETE FORMS OF THIS RARE CONDITION. Link: Click here to read article Title: FAMILIAL INTESTINAL POLYPOSIS WITH PIGMENTATION OF LIPS, ORAL MUCOSA, FACE, AND DIGITS Authors: H. H. WOLFF Journal: REPRINTED FROM LANCET Date: 1952 Abstract: JEGHERS ET AL. (1949) DRAW ATTENTION TO A RARE FAMILIAL DISORDER IN WHICH MELANIN PIGMENTATION OF THE LIPS AND ORAL MUCOSA AND, IN SOME CASES, OF THE FACE AND DIGITS IS ASSOCIATED WITH POLYPOSIS OF THE GASTROINTESTINAL TRACT, ESPECIALLY THE SMALL INTESTINE. THESE WORKERS REPORT 10 CASES OF THIS SYNDROME SEEN BY THEM IN AMERICA AND MENTION 3 OTHERS. IN ADDITION THEY REVIEW 12 PROVEN AND 5 PROBABLE CASES RECORDED BY OTHER AUTHORS. Link: Click here to read article Title: THE SYNDROME OF GENERALIZED INTESTINAL POLYPOSIS AND MELANIN SPOTS OF THE ORAL MUCOSA, LIPS, AND DIGITS Authors: ARNOLD B. SCHAFFER, SEYMOUR W. SACHS Journal: REPRINTED FROM ORAL SURGERY, ORAL MEDICINE, AND ORAL PATHOLOGY Date: 1952 Abstract: BY VIRTUE OF COMMENDABLE DILIGENT EFFORT DRS. JEGHERS, MCKUSICK, AND KATZ HAVE ESTABLISHED A SYNDROME WHICH IS OF DEFINITE INTEREST TO THE DENTAL PROFESSION. THIS IS "THE SYNDROME OF GENERALIZED INTESTINAL. POLYPOSIS AND MELANIN SPOTS OF THE ORAL MUCOSA, LIPS, AND DIGITS. KNOWLEDGE OF THIS ENTITY BY THE DENTAL SURGEON MAY RESULT IN HIS RENDERING A VALUABLE DIAGNOSTIC SERVICE. Link: Click here to read article Title: GENERALIZED INTESTINAL POLYPOSIS WITH MELANOSIS: REPORT OF A CASE Authors: RODERICK ANDREW Journal: GASTROENTEROLOGY Date: 1953 Abstract: IN 1944 JEGHERS REPORTED MELANIN PIGMENTATION OF THE MOUTH, LIPS AND FINGERS OF TWO PATIENTS IN WHOM INTESTINAL POLYPOSIS WAS PRESENT SUBSEQUENTLY, JEGHERS ET. AL. PUBLISHED AN ACCOUNT OF EIGHT FURTHER CASES. IN A FULL REVIEW OF THE LITERATURE WHICH UP TILL THEN HAD RECOGNIZED THE ESSENTIAL UNITY OF THE SYNDROME ONLY IN A LIMITED WAY. Link: Click here to read article Title: POLYPOSIS OF SMALL INTESTINE WITH PIGMENTATION OF ORAL MUCOSA: REPORT OF TWO CASES Authors: A. P. KITCHIN Journal: BRITISH MEDICAL JOURNAL Date: 1953 Abstract: THE FOLLOWING CASES ARE RECORDED AS FURTHER EXAMPLES OF THIS CONDITION. THEY BOTH CAME TO HOSPITAL WITH SYMPTOMS OF INTESTINAL OBSTRUCTION DUE TO POLYPOSIS SECTION ONE HAVING HAD TWO PREVIOUS OPERATIONS FOR A SIMILAR CONDITION. THE TYPICAL PIGMENTATION IN THE ORAL REGION WAS PRESENT IN EACH CASE. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND BODY SURFACE PIGMENTATION Authors: Journal: SOUTHERN MEDICAL JOURNAL Date: 1954 Abstract: IN 1949 JEGHERS AND CO-WORKERS DESCRIBED AN INTERESTING SYNDROME CONSISTING OF MELANIN PIGMENTED AREAS ON THE LIPS AND IN THE ORAL CAVITY ACCOMPANIED BY GENERALIZED INTESTINAL POLYPOSIS. SINCE THIS TIME AN INCREASING NUMBER OF SUCH INDIVIDUALS HAVE BEEN OBSERVED BY CLINICAL INVESTIGATORS. RECENTLY, BRUWER HAS PUBLISHED A CASE REPORT TOGETHER WITH A REVIEW OF THE LITERATURE ON 30 INDIVIDUALS REPORTED AFFECTED WITH THIS SYNDROME. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH PIGMENTATION OF THE ORAL MUCOSA Authors: W. P. CRONE, A. LAWSON LIGHT Journal: BRITISH MEDICAL JOURNAL Date: 1954 Abstract: THIS SYNDROME WAS DESCRIBED BY PEUTZ (1921) AND AGAIN BY JEGHERS (1944), WHO LATER COLLECTED A FURTHER 22 CASES FROM THE WORLD'S LITERATURE. OF THE 30 PATIENTS SO FAR REPORTED FEW PROVED CASES HAVE BEEN DESCRIBED IN THE BRITISH ISLES . IN VIEW OF THE APPARENT RARITY OF THE CONDITION, WHICH MAY YET PROVE TO BE MORE COMMON THAN IS AT PRESENT SUPPOSED, TWO FURTHER CASES ARE CONSIDERED WORTH RECORDING. Link: Click here to read article Title: INTESTINAL POLYPOSIS WITH MELANIN SPOTS OF ORAL MUCOSA, LIPS, AND FINGERS Authors: Journal: JAMA Date: 1954 Abstract: PEUTZ OF HAGUE DESCRIBED IN 1921 A FAMILY IN WHICH SEVERAL MEMBERS HAD PIGMENTED SPOTS ON THE LIPS, MOUTH, HANDS, AND FEET. THE CHARACTERISTIC PIGMENTATION WAS ASSOCIATED WITH GENERALIZED INTESTINAL POLYPOSIS IN SEVEN OF THESE PERSONS. THE CASES COVERED THREE GENERATIONS, THUS SUGGESTING A FAMILIAL TENDENCY. Link: Click here to read article Title: SMALL-INTESTINE POLYPOSIS ASSOCIATED WITH A CHARACTERISTIC CIRCUMORAL PIGMENTATION Authors: MERVYN SMITH Journal: REPRINTED FROM BRITISH JOURNAL OF SURGERY Date: 1954 Abstract: IN 1896, JONATHAN HUTCHINSON DESCRIBED IN A PAIR OF TWINS THE OCCURRENCE OF AN UNUSUAL TYPE OF BLACK PIGMENTATION ON THE LIPS AND MUCOUS MEMBRANE OF THE MOUTH. PARKES WEBER (1919) STATED THAT ONE OF THE TWINS HAD DIED WITH AN INTUSSUSCEPTION AT THE AGE OF 20, BUT IT IS ONLY MORE RECENTLY THAT THE PROBABLE NATURE OF THE CONDITION HAS BEEN REVEALED. Link: Click here to read article Title: SURFACE PIGMENTATION AND GENERALIZED INTESTINAL POLYPOSIS (PEUTZ-JEGHERS SYNDROME) Authors: ANDRE BRUWER, J. ARNOLD BARGEN, ROBERT R. KIERLAND Journal: STAFF MEETINGS OF THE MAYO CLINIC Date: 1954 Abstract: THE FOLLOWING CASE, OF GENERALIZED INTESTINAL POLYPOSIS ASSOCIATED WITH MELANIN PIGMENT SPOTS OF THE LIPS IS PRESENTED BRIEFLY TO DRAW ATTENTION TO THIS INTERESTING ASSOCIATION. EVEN THOUGH THE SYNDROME APPARENTLY IS RARE, IT WOULD APPEAR FROM DESCRIPTIONS GIVEN TO BE SO STRIKING THAT, ONCE KNOWN, ITS RECOGNITION SHOULD PRESENT NO DIFFICULTY TO THE CLINICIAN. Link: Click here to read article Title: SYNDROME OF PEUTZ (MELANOPLAKIA AND INTESTINAL POLYPOSIS): OBSERVATIONS WITH SPECIAL REFERENCE TO THE ORAL PIGMENTATION Authors: MILLARD A. TROXELL Journal: REPRINTED FROM ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY Date: 1954 Abstract: MELANOPLAXIA - A BROWN-BLACK ORAL MUCOSAL PIGMENTATION-IS LITERALLY A "BLACK PLATE," AND BY DEFINITION THE PIGMENT NEED NOT BE MELANIN. IT HAS BEEN DESCRIBED UNDER VARIOUS TERMS BUT MOST PROBABLY IS A LENTIGO. ALTHOUGH OPINIONS DIFFER, THE RED FREE MARGINS OF THE LIPS ARE HEREIN CONSIDERED AS MUCOUS-RATHER THAN CUTANEOUS-SURFACES. Link: Click here to read article Title: SYNDROME OF POLYPOSIS AND MELANIN PIGMENTATION Authors: W. GLENN YOUNG, JR. Journal: MODERN MEDICINE Date: 1954 Abstract: W. GLENN YOUNG, JR., M. D., OF DUKE UNIVERSITY, DURHAM, N. C., FINDS THAT A RARE BUT DANGEROUS FAMILY SYNDROME HAS 2 OUTSTANDING FEATURES: POLYPOSIS OF THE SMALL BOWEL, PARTICULARLY THE JEJUNUM, AND DISTINCTIVE MELANIN SPOTS OF THE BUCCAL MUCOSA AND LIPS. INTUSSUSCEPTION FREQUENTLY RESULTS, AND CANCER IS A POSSIBILITY. Link: Click here to read article Title: THE COINCIDENCE OF PERIORAL PIGMENTED SPOTS AND SMALL BOWEL POLYPS Authors: ROBERT A. WEBER Journal: REPRINTED FROM ANNALS OF SURGERY Date: 1954 Abstract: THE COINCIDENCE OF PERIORAL PIGMENTED SPOTS AND SMALL BOWEL POLYPS OCCURRING AS AN INHERITED FAMILIAL SYNDROME WAS FIRST DESCRIBED BY PEUTZ IN 1921. HUTCHINSON , IN 1896, REPORTED A CASE OF IDENTICAL TWINS WITH THE TYPICAL PERIORAL PIGMENTARY PATTERN WITHOUT ANY OTHER RECOGNIZED PATHOLOGICAL ABNORMALITY AT THAT TIME. Link: Click here to read article Title: FAMILIAL INTESTINAL POLYPOSIS WITH PIGMENTATION: TWO ADDITIONAL CASES Authors: W. RANKIN, A. P. LAIRD Journal: JAMA Date: 1955 Abstract: W. RANKIN, A. P. LAIRD. GLASGOW M. J. 35: 254-257 (OCT) 1954 [ GLASGOW , SCOTLAND ]. THE FIRST OF THE TWO CASES CONCERNED A 6-YEAR-OLD BOY WHO WAS HOSPITALIZED FOR INVESTIGATION OF ABDOMINAL PAIN AND REPEATED SMALL HEMATEMESIS. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND PIGMENTATION OF THE LIP: REPORT OF A CASE Authors: E. L. CRUMPACKER Journal: REPRINTED FROM NEW ENGLAND JOURNAL OF MEDICINE Date: 1955 Abstract: THE STRANGE ASSOCIATION OF INTESTINAL POLYPOSIS AND MELANOTIC SPOTS OF THE ORAL MUCOUS MEMBRANES WAS UNRECOGNIZED IN THE ENGLISH AND AMERICAN LITERATURE AS A SYNDROME OF DIAGNOSTIC SIGNIFICANCE UNTIL RECENTLY. WITH THEIR CLASSIC DESCRIPTION IN 1919, JEGHERS AND HIS CO-WORKERS ALERTED THE MEDICAL PROFESSION TO THE PUZZLING ASSOCIATION OF THESE TWO RARE CONDITIONS. THESE AUTHORS EXHAUSTIVELY REVIEWED PREVIOUS ARTICLES IN THE WORLD LITERATURE. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH ABNORMAL PIGMENTATION OF THE MUCOUS MEMBRANES AND SKIN: PEUTZ-JEGHER SYNDROME Authors: FRANK SOHMER, DAVID CAYER Journal: NORTH CAROLINA MEDICAL JOURNAL Date: 1955 Abstract: IN 1949 JEGHERS REVIEWED A CLINICAL ENTITY CONSISTING OF INTESTINAL POLYPOSIS ASSOCIATED WITH ABNORMAL PIGMENTATION OF THE SKIN AND MUCOUS MEMBRANES. SINCE THIS COMPREHENSIVE SURVEY, ADDITIONAL CASES HAVE BEEN RECOGNIZED AND REPORTED. THE HEREDITARY NATURE OF THIS SYNDROME HAS BEEN ESTABLISHED, ALTHOUGH SPORADIC CASES HAVE BEEN NOTED. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH PIGMENTATION OF THE LIPS, BUCCAL MUCOSA AND DIGITS Authors: JAMES H. STEWART, CLIFFORD F. STOREY Journal: GASTROENTEROLOGY Date: 1955 Abstract: THE SYNDROME OF INTESTINAL POLYPOSIS ASSOCIATED WITH ABNORMAL PIGMENTATION OF THE LABIAL AND BUCCAL MUCOUS MEMBRANES IS A RARE BUT IMPORTANT CLINICAL ENTITY. SIR JONATHAN HUTCHINSON, IN 1896, FIRST DESCRIBED THE PECULIAR PIGMENTATION ABOUT THE LIPS AND BUCCAL MUCOSA WHICH CHARACTERIZES THIS SYNDROME. HE OBSERVED THE PIGMENTATION IN IDENTICAL TWINS, ONE OF WHOM DIED OF INTUS-SUSCEPTION AT THE AGE OF 20. Link: Click here to read article Title: PIGMENTED SPOTS OF THE ORAL MUCOSA, LIPS AND DIGITS ASSOCIATED WITH GASTRO-INTESTINAL POLYPOSIS Authors: ALLEN I. BORTZ, FRANK H. BETHELL Journal: REPRINTED FROM ANNALS OF INTERNAL MEDICINE Date: 1955 Abstract: THE COMPLETE SYNDROME OF INTESTINAL POLYPOSIS AND MELANIN SPOTS OF THE ORAL MUCOSA, LIPS AND DIGITS WAS FIRST DESCRIBED BY JEGHERS IN 1944. HOWEVER, AS EARLY AS 1896 HUTCHINSON REPORTED UNUSUAL BLACK PIGMENTED SPOTS ON THE FACE AND ORAL MUCOSA OF TWINS, AND WEBER IN 1919 REPORTED THAT ONE OF THESE TWINS DIED OF INTUSSUSCEPTION AT THE AGE OF 20. Link: Click here to read article Title: POLYPS AND PIGMENT IN THE PEUTZ-JEGHERS SYNDROME Authors: JOSEPH T. FREEMAN, ISIDOR S. RAVDIN Journal: REPRINTED FROM NEW ENGLAND JOURNAL OF MEDICINE Date: 1955 Abstract: THE CLINICAL CONDITION DESCRIBED BY PEUTZ, OF HOLLAND , IN 1921 WAS CHARACTERIZED BY HIM AS A REMARKABLE SITUATION OF FAMILIAL POLYPOSIS OF THE MUCOSA OF THE SMALL INTESTINE WITH UNUSUAL SKIN AND MUCOSAL PIGMENTATION. GENERALLY, THE PATTERN CONSIST OF MELANOSIS IN THE FACIAL AND DIGITAL SKIN AS WELL AS BUCCAL AND OTHER MUCOSAL SITES ASSOCIATED WITH POLYPS OF THE SMALL INTESTINES. Link: Click here to read article Title: INTESTINAL POLYPOSIS Authors: Journal: PFIZER SPECTRUM Date: 1956 Abstract: INTESTINAL POLYPOSIS THE PECULIAR ASSOCIATION OF POLYS OF THE GASTROINTESTINAL TRACT WITH MELANIN DEPOSITS ON THE LIPS AND ON THE SKIN OF THE FACE AND DIGITS HAS ATTAINED THE DIGNITY OF BEING NAMED THE PEUTZ-JEGHERS SYNDROME. THE CONDITION WAS ORIGINALLY ESCRIBED IN 1921 BY J. L. A. PEUTZ ( THE HAGUE , NETHERLANDS ) ; THE FIRST REPORT IN THIS COUNTRY WAS A STUDY OF 10 CASES MADE BY H. J. JEGHERS ( GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE) AND HIS CO-WORKERS. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND ORAL PIGMENTATION: CASE REPORT Authors: ROLAND W. RICHTERICH-VAN BAERLE, W. W. BYRNES, SAUL SCHEFF Journal: ANNALS OF INTERNAL MEDICINE Date: 1956 Abstract: "A VERY REMARKABLE CASE OF FAMILIAL POLYPOSIS OF THE MUCOUS MEMBRANES, OF THE INTESTINAL TRACT, AND THE NASOPHARYNX ACCOMPANIED BY PECULIAR PIGMENTATION OF THE SKIN, AND THE MUCOUS MEMBRANES" IS THE TITLE OF AN ARTICLE BY PEUTZ. TILE AUTHOR DESCRIBED SEVERAL MEMBERS OF A FAMILY WITH SOME OR ALL OF THE MANIFESTATIONS OF THIS UNIQUE SYNDROME. Link: Click here to read article Title: PEUTZ'S SYNDROME Authors: THOMAS L. DORMANDY, JOHN H. EDWARDS Journal: GASTROENTEROLOGIA Date: 1956 Abstract: PEUTZ'S SYNDROME HAS THREE CARDINAL FEATURES: G-ASTRO-INTESTINAL POLYPOSIS, A DISTINCTIVE TYPE OF PIGMENTATION, AND INHERITANCE THROUGH A MEDELIAN DOMINANT GENE. THOUGH THE POLYPOSIS MAY INVOLVE ALL PARTS OF THE GUT, THE SMALL INTESTINE IS ALWAYS AFFECTED Link: Click here to read article Title: FAMILIAL POLYPOSIS OF THE INTESTINE AND PIGMENTATION: (PUETZ-JEGHERS SYNDROME) Authors: AARNE RINTALA, C. E. NYLUND Journal: ACTA CHIRURGICA SCANDINAVICA Date: 1957 Abstract: PEUTZ-JEGHERS SYNDROME IS A HEREDITARY, RARE CONDITION CONSISTING OF POLYPOSIS THROUGHOUT THE GASTROINTESTINAL TRACT AND MELANIN PIGMENTATION OF THE SKIN AND ORAL MUCOSA. THE FOLLOWING DESCRIPTION IS BASED ON FOUR CASES SEEN BY US AND A SURVEY OF THE LITERATURE. Link: Click here to read article Title: GASTROINTESTINAL POLYPOSIS AND PIGMENTATION OF THE ORAL MUCOSA (PEUTZ-JEGHERS SYNDROME) Authors: CHARLES J. STALEY, HENRY SCHWARZ, II. Journal: REPRINTED FROM SURGERY, GYNECOLOGY AND OBSTETRICS Date: 1957 Abstract: IN 1949 JEGHERS, MCKUSICK, AND KATZ BROUGHT TO THE ATTENTION OF THE PROFESSION AN OBSCURE BUT PREVIOUSLY DESCRIBED SYNDROME CONSISTING OF "GENERALIZED INTESTINAL POLYPOSIS AND MELANIN SPOTS OF THE ORAL MUCOSA, LIPS, AND DIGITS." SINCE THE SYNDROME HAD APPARENTLY BEEN INITIALLY DESCRIBED BY PEUTZ (1921) NO ORIGINALITY WAS CLAIMED. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND PIGMENTED SPOTS OF LIPS: HEREDITARY PEUTZ-JEGHERS SYNDROME Authors: LLOYD C. ROHRS Journal: REPRINTED FROM JAMA Date: 1957 Abstract: REPEATED EPISODES OF ABDOMINAL PAIN IN PERSONS HAVING MELANIN SPOTS WITH A CHARACTERISTIC DISTRIBUTION CAN, WITH STRONG SUSPICION, DENOTE EXISTENT INTESTINAL POLYPS. TYPICALLY THE MELANIN SPOTS ARE ON NOT ONLY THE LIPS AND LABIAL MUCOUS MEMBRANE BUT ALSO THE BUCCAL MUCOSA, OCCASIONALLY THE GINGIVA AND HARD PALATE, AND RARELY AN THE TONGUE. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH MUCOCUTANEOUS MELANIN PIGMENTATION (PEUTZ-JEGRERS SYNDROME) Authors: LLOYD G. BARTHOLOMEW, DAVID C. DAHLIN, JOHN M. WAUGH Journal: PROCEEDINGS OF THE MAYO CLINIC Date: 1957 Abstract: INTESTINAL POLYPOSIS WITH MUCOCUTANEOUS PIGMENTATION IS A. RARE MEDICAL CURIOSITY. THIS SYNDROME WAS FIRST DESCRIBED BY THE DUTCH PHYSICIAN, PEUTZ, IN 1921 WHEN HE DOCUMENTED SEVEN INSTANCES OCCURRING IN A SINGLE FAMILY. SPORADIC CASES WERE REPORTED UNTIL 1949, WHEN JEGHERS MADE HIS CONTRIBUTION. Link: Click here to read article Title: INTESTINAL POLYPOSIS ASSOCIATED WITH MUCOCUTANEOUS: MELANIN PIGMENTATION (PEUTZ-JEGHER SYNDROME) Authors: LLOYD G. BARTHOLOMEW, DAVID C. DAHLIN, JOHN M. WAUGH Journal: GASTROENTEROLOGY Date: 1957 Abstract: RARE DISEASES HAVE A TENDENCY TO BECOME MORE COMMON AS INTEREST AND DIAGNOSTIC ACUMEN BECOME FOCUSED IN THEIR DIRECTION. THIS APPEARS TO BE THE SITUATION IN THE CURIOUS COMBINATION REFERRED TO AS THE PEUTZ-JEGHERS SYNDROME. THIS SYNDROME CONSISTS OF MUCOCUTANEOUS MELANIN PIGMENTATION AND INTESTINAL POLYPOSIS. Link: Click here to read article Title: PEUTZ-JEGHERS SYNDROME: FOLLOW-UPS ON PATIENTS REPORTED ON IN THE LITERATURE Authors: AUSTIN H. KUTSCHER, EDWARD V. ZEGARELLI, ROBIN M. RANKOW Journal: AMERICAN JOURNAL OF THE MEDICAL SCIENCES Date: 1957 Abstract: SINCE 1949, WHEN JEGHER, MCKUSICK, AND KATZ CALLED ATTENTION TO THE DIAGNOSTIC IMPORTANCE OF AN UNUSUAL FAMILIAL DISORDER (PREVIOUSLY DESCRIBED BY AND KNOWN AS THE SYNDROME OF PEUTZ) AND THE PUBLICATION IN 1945 OF AN EDITORIAL IN THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, THERE HAS BEEN AN AWAKENING OF INTEREST IN THIS SYNDROME. FROM THE NUMBER OF CASES APPEARING IN THE LITERATURE THEREAFTER, ONE CAN ASSUME THAT IT IS NOT AS RARE A DISEASE AS WAS ONCE THOUGHT. PEUTZ-JEGHERS SYNDROME IS... Link: Click here to read article Title: POLYPOSIS GASTRO-INTESTINAL TRACT: THE PEUTZ SYNDROME Authors: DAVID BAILEY Journal: BRITISH MEDICAL JOURNAL Date: 1957 Abstract: THE ASSOCIATION OF MULTIPLE ADENOMATA OF THE GASTROINTESTINAL TRACT WITH MULTIPLE PIGMENTATION OF THE ORAL MUCOSA, LIPS, AND FACE WAS FIRST DESCRIBED BY PEUTZ (1921), BUT HIS DESCRIPTION ATTRACTED LITTLE ATTENTION AT THE TIME. THE SUBJECT WAS FULLY REVIEWED BY JEGHER ET. AL. (1949), AND SINCE THEN MANY CASES HAVE BEEN REPORTED. Link: Click here to read article Title: GENERALIZED INTESTINAL POLYPOSIS WITH MELANOTIC PLAQUES OF THE LIPS, ORAL MUCOSA, AND FINGERS; PEUTZ-JEGHERS SYNDROME Authors: J. C. ROSENBERG Journal: INTERNATIONAL ABSTRACTS OF SURGERY Date: 1958 Abstract: (POLYPOSIS INTESTINALIS GENERALISATA MIT MELANOPLAKIEN DER LIPPEN, ORALEN MUCOSA UND FINGER; SYNDROM VON PEUTZ-JEGHERS). R. RICHTERICH, H. J. KAUFMANN. SCHWEIZ. MED WSCHR., 1957, 87: 552. Link: Click here to read article Title: INTESTINAL POLYPOSIS AND MUCOCUTANEOUS PIGMENTATION (PEUTZ-JEGHERS SYNDROME) FURTHER COMMENTS AND REPORT OF AN ADDITIONAL CASE Authors: LLOYD G. BARTHOLOMEW, DAVID C. DAHLIN Journal: REPRINTED FROM MINNESOTA MEDICINE Date: 1958 Abstract: PEUTZ-JEGHERS SYNDROME HAS LEFT THE REALM OF MEDICAL CURIOSITIES TO BECOME A WELL-RECOGNIZED ENTITY. AS EVIDENCE OF THIS, THE AUTHORS HAVE COLLECTED DATA IN 117 CASES. THIS SYNDROME CONSISTS OF MUCOCUTANEOUS PIGMENTATION ASSOCIATED WITH INTESTINAL POLYPOS IS. THE AUTHORS MAINTAIN THAT THE POLYPS IN THIS SYNDROME ARE BENIGN, WHEREAS OTHER OBSERVERS CLAIM THAT MANY OF THEM ARE POTENTIALLY MALIGNANT. THE READER IS INVITED TO PERUSE THE EVIDENCE AND DECIDE FOR HIMSELF. Link: Click here to read article
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Jeghers Medical Index, St. Elizabeth Health Center, 1044 Belmont Ave., Youngstown, OH 44501
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