Peutz-Jeghers Syndrome - JMI Articles

Articles from our collection about Peutz-Jeghers Syndrome published about histology/pathology

Title: Overexpression of epidermal growth factor receptor in Peutz-Jeghers syndrome

Authors: McGarrity TJ;Peiffer LP;Billingsley ML;

Journal: Dig Dis Sci Date: 1999 Jun
Volume: 44 Issue: 6
Pages: 1136 - 1141

Abstract: Peutz-Jeghers syndrome is characterized by gastrointestinal hamartomatous polyposis, mucocutaneous pigmentation, and a predisposition to cancer. The etiology of this syndrome is unknown. We investigated the expression of epidermal growth factor receptor (EGFr), transforming growth factor-alpha (TGF-alpha), transforming growth factor-beta1 (TGF-beta1) and transforming growth factor-beta receptor (TGF-beta RII) between normal and Peutz-Jeghers small bowel tissues. In addition, immunoprecipitation by phosphotyrosine antibodies followed by EGFr western blotting was measured and compared between a Peutz-Jeghers hamartoma and normal duodenal tissue. EGFr expression was increased 2.5-fold in normal and hamartomatous tissue of Peutz-Jeghers patients compared to normal small bowel tissue. In Peutz-Jeghers tissues, the major EGFr immunoreactive band was increased size from 170 to approximately 200 kDa. Using an antibody specific for activated EGFr, this larger size band was predominant in Peutz-Jeghers tissue. Immunoprecipitation of a hamartoma by a phosphotyrosine specific antibody followed by western blotting for EGFr demonstrated this 200-kDa band. Expression of TGF-alpha, TGF-beta1, TGF-beta1 RII was not significantly different between normal and Peutz-Jeghers tissues. In conclusion, EGFr was overexpressed in normal and hamartomatous small bowel tissue of Peutz-Jeghers patients, which suggests that EGFr in Peutz-Jeghers tissue is persistently activated or highly stimulated by endogenous ligands and also suggests a possible role for EGFr in the pathogenesis of Peutz-Jeghers syndrome

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Title: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1975

Authors:

Journal: N Engl J Med Date: 1975 Jun 19
Volume: 292 Issue: 25
Pages: 1340 - 1345

Abstract:

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Title: SOME PECULIARITIES IN THE HISTOLOGY OF INTESTINAL POLYPS

Authors: BASIL C. MORSON

Journal: DISEASES OF THE COLON AND RECTUM Date: 1962
Volume: 5 Issue:
Pages: 337-344

Abstract: IT IS UNFORTUNATE, AND POSSIBLY FRAUGHT WITH DANGER, THAT THE WORD POLYP, WHICH SHOULD BE USED PURELY AS A CLINICAL DESCRIPTION OF ANY SMALL TUMOR PROJECTING FROM THE INTESTINAL MUCOUS MEMBRANE, HAS BECOME SYNONYMOUS, BOTH IN THE LITERATURE AND DURING CONVERSATION, WITH THE WORD "ADENOMA." SUCH A LACK OF PRECISION IN NAMING PATHOLOGIC CONDITIONS LEADS NOT ONLY TO FALSE CONCEPTIONS OF THE TRUE CHARACTER OF THE DISORDER, BUT ALSO TO IMPROPER TREATMENT.

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Title: THE HISTOLOGICAL APPEARANCE OF GASTROINTESTINAL POLYPS IN THE PEUTZ-JEGHERS SYNDROME

Authors: AARNE RINTALA

Journal: ACTA CHIRURGICA SCANDINAVICA Date: 1959
Volume: 117 Issue:
Pages: 366-373

Abstract:

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Title: INFLAMMATORY PSEUDOPOLYPOSIS OF THE SMALL AND LARGE INTESTINES WITH THE PEUTZ-JEGHERS SYNDROME IN A CASE OF DIFFUSE HISTOPLASMOSIS

Authors: SOLOMON R. BERSACK, JOHN S. HOWE, ALAN S. RABSON

Journal: AMERICAN JOURNAL OF ROENTGENOLOGY Date: 1958
Volume: 80 Issue: 1
Pages: 73-78

Abstract: RECENTLY A PATIENT WAS ENCOUNTERED WHO CLINICALLY PRESENTED THE FEATURES OF THE PEUTZ-JEGHERS SYNDROME BUT THE INTESTINAL MANIFESTATIONS PROVED TO BE INFLAMMATORY NONADENOMATOUS PSEUDOPOLYPS. THE RARITY OF SUCH AN OCCURRENCE SEEMS TO WARRANT THIS CASE REP

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Title: ORAL MELANIN PIGMENTATION IN INTESTINAL POLYPOSIS: HISTOPATHOLOGIC CONSIDERATIONS

Authors: EDWARD V. ZEGARELLI, AUSTIN H. KUTSCHER, JOHN D. PIRO

Journal: REPRINTED FROM AMERICAN JOURNAL OF DIGESTIVE DISEASE Date: 1956
Volume: 1 Issue: 11
Pages: 455-465

Abstract: IN 1949, JEGHERS, MCKUSICK, AND KATZ, AGAIN CALLED ATTENTION TO THE DIAGNOSTIC IMPORTANCE OF AN UNUSUAL FAMILIAL DISORDER (PREVIOUSLY DESCRIBED BY AND KNOWN AS THE SYNDROME OF PEUTZ) CHARACTERIZED BY MELANIN SPOTS OF THE LIPS AND MOUTH AND, TO A LESSER DEGREE, OF THE SKIN, IN ASSOCIATION WITH POLYPOSIS OF THE INTESTINE. THEREAFTER, NUMEROUS REPORTS HAVE ESTABLISHED THIS SYNDROME AS OF CONSIDERABLE IMPORTANCE AND NOT UNCOMMON.

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